"Any ideas?"
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Kevin P.
Hi there!
Shingles causes neuropathic pain; the research regarding CBD and neuropathic pain is sparse. Although, in a study published in the British Journal of Pharmacology, researchers found that chronic administration of CBD prevents paclitaxel-induced neuropathy (PAC) (paclitaxel is a common chemotherapy agent which often causes neuropathic pain). Interestingly, they found that the cannabinoid receptors CB1 and CB2 were not involved in preventing the pain from developing. Rather, they concluded that CBD is protective against PAC-induced neurotoxicity mediated in part by the serotonin receptor system. Modulation of the serotonin receptor system is also the method that antidepressant drugs are thought to affect neuropathic pain.
https://www.ncbi.nlm.nih.gov/pubmed/24117398
However, there is a significant amount of research showing that Sativex — an oromucosal spray with 1CBD:1THC — effectively reduces neuropathic pain. In 2005, Sativex was approved in Canada for the treatment of central neuropathic pain in multiple sclerosis, and in 2007 for intractable cancer pain. Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
I hope this helps!
drkim
